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CPK may refer to:

  • C, a measure of process capability
  • CPK coloring, a way to color atoms when visualizing molecular models
  • "C.P.K." (Unwritten Law song)
  • Cabbage Patch Kids
  • California Pizza Kitchen
  • Carpenders Park railway station, England (National Rail station code)
  • Chesapeake Utilities (New York Stock Exchange symbol)
  • Church of the Province of Kenya, a former name for the Anglican Church of Kenya
  • Communist Party of Kampuchea, commonly known as the Khmer Rouge
  • Composite primary key, a primary key comprising more than one field
  • Creatine phosphokinase, an enzyme found in humans, or alternatively a blood test for it