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Coyame (formally: Santiago de Coyame) is a town in the Mexican state of Chihuahua. It serves as the municipal seat of Coyame del Sotol Municipality.

In the 2010 INEGI Census, the town reported a total population of 709.

It was founded in 1715 by the Spanish explorer Juan Antonio Traviña y Retes.

Coyame is also the location of a hot spring and a cave system.