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Comahue is a sub-region of Argentina slightly to the south of the country's centre that covers the northern part of Argentine Patagonia and includes the provinces of Neuquén and Río Negro. Some also include La Pampa Province and the Patagones Partido at the southern tip of Buenos Aires Province.

The region's social and economical centre is located at the point where the Limay and Neuquén rivers join into the Río Negro. This fertile, orchard-lined area is known as the Alto Valle del Río Negro and the main cities in the zone are Neuquén, seat of the National University of Comahue and General Roca.