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Clustal

In Bioinformatics Clustal is a series of widely used computer programs for multiple sequence alignment. There have been many incarnations of Clustal that are listed below:

  • Clustal: The original software for progressive alignment based on a phylogenetic tree.
  • ClustalV: A rewrite of the original Clustal package that included phylogenetic tree reconstruction on the final alignment for the first time.
  • ClustalW: command line interface
  • ClustalX: This version has a graphical user interface.
  • Clustal Omega: Command line-only program.

The papers describing the clustal software have been very highly cited, with two appearing in a list of the most cited papers of all time.

The more recent version of the software available for Windows, Mac OS, and Unix/Linux. This program is available from the Clustal Homepage or European Bioinformatics Institute ftp server.