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CLC may refer to:

CLC (gene)

Eosinophil lysophospholipase is an enzyme that in humans is encoded by the CLC gene.

CLC (band)

CLC is a South Korean girl group formed by Cube Entertainment in 2015. The group consists of Seunghee, Yujin, Seungyeon, Sorn, Yeeun, Elkie and Eunbin. CLC is an initialism which stands for CrystaL Clear. CLC made their debut with the release of their EP First Love on March 19, promoting the title track Pepe.