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CIMOSA, standing for "Computer Integrated Manufacturing Open System Architecture", is an enterprise modeling framework, which aims to support the enterprise integration of machines, computers and people. The framework is based on the system life cycle concept, and offers a modelling language, methodology and supporting technology to support these goals.

It was developed in the 1990s by the AMICE Consortium, in an EU project. A non-profit organization CIMOSA Association was later established to keep ownership of the CIMOSA specification, to promote it and to support its further evolution.