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Chx may refer to:

  • Chamonix, a town in the French Alps
  • Chancellor of the Exchequer
  • Chicago Stock Exchange
  • Charing Cross railway station ( National Rail code) in London
  • Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque
  • CHX, the IATA airport code for Changuinola "Capitán Manuel Niño" International Airport in Changuinola, Panama
  • Cycloheximide, an inhibitor of protein biosynthesis in eukaryotic cells