What is "chemogenetics"

The term chemogenetics has been used to describe the processes by which macromolecules can be engineered to interact with previously unrecognized small molecules. Chemogenetics as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on substrate specificities in the flowers of Dianthus caryophyllus. Such engineered macromolecules include nucleic acid hybrids, kinases a variety of metabolic enzymes, and G-protein coupled receptors (GPCRs) such as DREADDs.