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CGB may refer to:

  • Cambridgeshire Guided Busway
  • Chorionic gonadotropin beta, glycoprotein hormone
  • Christlichen Gewerkschaftsbund Deutschlands, the German Christian Workers' Federation
  • Clarence Gatemouth Brown, acclaimed multi-instrumentalist, but best known for his guitar work in traditional blues
  • C.G.B. Spender, a fictional character in the television series The X-Files
  • Compagnie des Chemins de Fer de Grande Banlieue or CGB, a defunct railway in France
  • Consumer & Governmental Affairs Bureau part of FCC
  • Cosmic gravitational wave background, a relict of the cosmic inflation in the cosmic microwave background radiation
  • Game Boy Color (known as CGB in development)
  • Marechal Rondon International Airport, (IATA airport code) in Cuiabá, Mato Grosso, Brazil
  • Colegio Gran Bretaña, a private international school in Bogotá, Colombia