CDH may refer to:
- Central DuPage Hospital, Illinois, U.S.A.
- Centre Démocrate Humaniste, a Belgian political party
- Cloudera's Distribution including Apache Hadoop
- The Computational Diffie-Hellman assumption, that a certain mathematical problem is hard
- Congenital diaphragmatic hernia
- Cretin-Derham Hall, school in St. Paul, Minnesota, U.S.A.
- Cellobiose dehydrogenase, a plant enzyme