What is "cbfb"

Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.

Mutations in CBFB are implicated in cases of breast cancer.

Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. It is most commonly caused by an inversion of particular region of chromosome 16; however it can also be caused by translocation between copies of chromosome 16. The rearrangements cause formation of CBF but with impaired function. This prevents proper differentiation of blood cells, leading to the formation of Myeloblast.