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Castelpizzuto is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about west of Campobasso and about southeast of Isernia. As of 31 December 2004, it had a population of 156 and an area of .

Castelpizzuto borders the following municipalities: Castelpetroso, Longano, Pettoranello del Molise, Roccamandolfi, Santa Maria del Molise.