Calne is a town and civil parish in Wiltshire, southwestern England, at the northwestern extremity of the North Wessex Downs hill range, a designated Area of Outstanding Natural Beauty.
Calne is on a small river, the Marden, that rises away in the Wessex Downs, and is the only town on that river. It is on the A4 road national route east of Bath, east of Chippenham, west of Marlborough and southwest of Swindon. Wiltshire's county town of Trowbridge is to the southwest, with London due east as the crow flies. At the 2011 Census, Calne had 17,274 inhabitants.
Calne was a parliamentary borough in Wiltshire, which elected two Members of Parliament (MPs) to the House of Commons from 1295 until 1832, and then one member from 1832 until 1885, when the borough was abolished.