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Calmette is a surname. Notable people with the surname include:

  • Antoine de Bosc de la Calmette (1752–1803), Danish governor and landscape architect
  • Albert Calmette ForMemRS (1863–1933), French physician, bacteriologist, immunologist, officer of the Pasteur Institute
  • Gaston Calmette (1858–1914), French journalist
  • Jean Calmette (1692–1740), French Jesuit missionary in South India, Indologist