Bletsoe is a village and civil parish in Bedfordshire, England. It is on the A6, and about eight miles north of Bedford. The village has a small park, the former site of Bletsoe Castle and a church. Nearby places are Sharnbrook, Milton Ernest, Riseley, Thurleigh, Odell, Souldrop, and Swineshead. The nearest town to Bletsoe is Rushden, over the border in Northamptonshire.
The small hamlet of Bourne End borders Bletsoe and is part of the civil parish.
Bletsoe Castle was the birthplace of Margaret Beaufort. She was the mother of Henry VII and grandmother of Henry VIII.