Betsiboka is a region of Madagascar. It borders Boeny Region in north, Sofia in northeast, Alaotra-Mangoro in east, Analamanga and Bongolava in south and Melaky in west. The capital of the region is Maevatanana. Until 2009 Betsiboka belonged to Mahajanga Province. The population was estimated to be 301,480 in 2014 within the area of . Betsiboka is one of the least densely populated regions in Madagascar.