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ASTC may refer to:

  • Association of Science-Technology Centers, an international organization of science centers and science museums
  • Antonov ASTC (Antonov Aeronautical Scientific/Technical Complex), a Ukraine-based aircraft manufacturing and services company
  • All Students Take Calculus, a mathematical mnemonic
  • Active Skid and Traction Control, the brand name of Mitsubishi Motors' electronic stability control system
  • ASX Settlement and Transfer Corporation, the operator of the Australian Clearing House and Electronic Sub-register System (CHESS)
  • Alamo Scouts Training Center, the training camp and headquarters of the U.S. Sixth Army Special Reconnaissance
  • Assam State Transport Corporation, the road transport authority of the state of Assam, India
  • Alice Springs Town Council, the local council for the Central Australian township of Alice Springs, Northern Territory, Australia
  • Adaptive Scalable Texture Compression, a lossy block-based texture compression algorithm
  • Succinylornithine transaminase, an enzyme