What is "aspartate transaminase"

n. (context enzyme English) An enzyme that catalyzes the transfer of amino groups between biologically active compounds, especially between aspartic acid and glutamic acid

Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or serum glutamic oxaloacetic transaminase (SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme that was first described by Arthur Karmen and colleagues in 1954. AST catalyzes the reversible transfer of an α-amino group between aspartate and glutamate and, as such, is an important enzyme in amino acid metabolism. AST is found in the liver, heart, skeletal muscle, kidneys, brain, and red blood cells. Serum AST level, serum ALT ( alanine transaminase) level, and their ratio ( AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.