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Apicata was a woman of the 1st century in ancient Rome. She was married to Sejanus, friend and confidant of the Roman Emperor Tiberius.

After Apicata had borne him three children, Sejanus divorced her in the year 23, when it seemed he might need to marry his lover and co-conspirator Livilla, the wife of Drusus Julius Caesar (son of Tiberius), and a woman of higher social rank than Apicata. Drusus was a challenger to Sejanus's quest for power, but died in 23 of apparent natural causes.