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The Collaborative International Dictionary
amyloidosis

amyloidosis \amyloidosis\ n. 1. a disorder characterized by deposit of amyloid in organs or tissues; often secondary to chronic rheumatoid arthritis or tuberculosis or multiple myeloma.

Wiktionary
amyloidosis

n. (context medicine English) Any of a group of disorders in which the fibrous protein amyloid is deposited in an organ of the body.

WordNet
amyloidosis

n. a disorder characterized by deposit of amyloid in organs or tissues; often secondary to chronic rheumatoid arthritis or tuberculosis or multiple myeloma

Wikipedia
Amyloidosis

Amyloidosis is a rare, serious disease caused by accumulation of proteins in the form of abnormal, insoluble fibres, known as amyloid fibrils, within the extracellular space in the tissues of the body. Amyloid fibrils are formed by aggregation (clumping) of normally soluble body proteins and accumulate progressively, forming amyloid deposits which disrupt the normal tissue architecture, damaging the function of tissues and organs and causing disease. In contrast to the normally efficient clearance of abnormal debris from the tissues, amyloid deposits are removed very slowly, if at all. There are many different types of amyloidosis, each caused by formation of amyloid fibrils from different soluble precursor proteins in different patients. About 30 different proteins are known to form amyloid fibrils in humans and amyloidosis is named and classified according to the identity of the respective fibril protein. Amyloid deposits can be confined to only one part of the body or a single organ system in ‘local amyloidosis’ or they can be widely distributed in organs and tissues throughout the body in ‘systemic amyloidosis’. The clinical manifestations of amyloidosis are accordingly highly variable and confirmation of the presence of amyloid in the tissues can be challenging, so that diagnosis is often delayed.