Wiktionary
amphipathic
a. 1 (context chemistry English) describing a molecule, such as a detergent, which has both hydrophobic and hydrophilic groups. 2 (context biochemistry English) often refers to the surface(s) on a protein, particularly an alpha helix, where one surface of the alpha helix has hydrophilic amino acids and the opposite face has hydrophobic (or lipophilic) amino acids.