In Greek mythology, the name Amphinome (Ἀμφινόμη) may refer to:
- Amphinome, a Nereid.
- Amphinome, wife of Aeson and mother to Jason and Promachus. She and her husband were persecuted by king Pelias of Iolcus. After Pelias had killed her husband and younger son, Amphinome stabbed herself with a sword. As she lay dying she pronounced a curse against the king.
- Amphinome, one of the daughters of Pelias, given by Jason in marriage to Andraemon, brother of Leonteus.
- Amphinome, wife of Arizelus and mother of Harpalion.