What is "alosetron"

n. A 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome in women.

Alosetron (original brand name: Lotronex ; originator: GSK) is a 5-HT antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. It is currently marketed by Prometheus Laboratories Inc. ( San Diego). Alosetron was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted.