Wikipedia
Ajacán in the province of Axacan, variants include Xacan, Jacan, Iacan, Axaca, Axacam; was located in the Mid-Atlantic near and including the Chesapeake Bay and present day Virginia, United States. In his 1842 Historia de la Compania de Fesus en Nueva Espana, Alegre said Father Juan Bautista de Segura and his companions called the province Axacan.
Some early 20th-century historians promoted the idea that the early Spanish explorers who made voyages into the Chesapeake Bay between 1565 and 1570 sailed up the Potomac River as far as Occoquan, Virginia, based on the similarity between "Axacan" of the Spanish missionary chronicles and the name of the Indian town and creek on the Potomac. The chronicles describe the failed Axacan mission in 1570, which included abandonment by their guide, and massacre of the party.