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AFX may stand for:

  • AFX Windows Rootkit 2003, a user-mode Windows rootkit that hides files, processes and registry
  • AFX News Limited, a London financial news agency
  • Animation Framework eXtension, a model for representing 3D graphics content defined in MPEG-4 Part 16
  • Aphex Twin (born 1971), electronic musician
  • Application Framework eXtensions, an old name for the Microsoft Foundation Class Library (MFC)
  • Aurora AFX, a brand of slot car marketed by Aurora Plastics Corporation
  • A replacement for the A-6 Intruder, developed by the United States Navy and United States Air Force (canceled in 1991)