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AFSC may stand for any of the following:

  • Affiliate of the Institute of the Brothers of the Christian Schools, used as post-nominal initials
  • American Friends Service Committee
  • Air Force Specialty Code
  • Air Force Systems Command
  • Air Force Space Command, often abbreviated as AFSPC to avoid confusion with the now defunct AF Systems Command.
  • Air Force School, Coimbatore, a school run by Indian Air Force.