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ACSS may refer to:

  • Academy of Social Sciences, the UK's national academy of academics, learned societies and practitioners in the scoail sciences
  • Afro Celt Sound System, a musical group which fuses modern dance rhythms with traditional Irish (Celtic) and West African music
  • Aluminium-conductor steel supported electrical cable
  • Antichrist Superstar, the second full-length studio album by Marilyn Manson
  • Aural Cascading Style Sheets, part of Cascading Style Sheets that makes a website more accessible to visually impaired and screen readers