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ACSC may refer to:

  • Ambulatory care sensitive conditions, a category of illnesses or health conditions
  • Advanced Casino Systems Corporation, a product group of Bally Technologies
  • Air Command and Staff College, Montgomery, Alabama
  • Alternating Closed and Semi-Closed rebreather, a special type rebreather for diving
  • Anderson Community School Corporation, Anderson, Indiana
  • Australian Command and Staff College, Weston Creek, Canberra
  • Automobile Club of Southern California