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ACOA may refer to:

  • Adult Children of Alcoholics, a twelve-step program
  • American Committee on Africa, an American nonprofit organization, now called Africa Action
  • Ant colony optimization algorithms, probabilistic techniques for solving computational problems that can be reduced to finding good paths through graphs
  • Anterior communicating artery, a blood vessel of the brain that connects the left and right anterior cerebral arteries
  • Atlantic Canada Opportunities Agency, the Canadian federal government agency responsible for helping to develop economic capacity in the Atlantic Provinces