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acanthosis

n. (context medicine English) A benign abnormal thickening of the stratum spinosum, or prickle cell, layer of the epidermis.(First attested in the late 19th century.)(R:SOED5)

WordNet
acanthosis

n. an abnormal but benign thickening of the prickle-cell layer of the skin (as in psoriasis)

Wikipedia
Acanthosis

Acanthosis is diffuse epidermal hyperplasia (thickening of the skin). It implies increased thickness of the Malpighian layer ( stratum basale and stratum spinosum).