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Answer for the clue "Man U get beaten by Spurs at last! They will make changes ", 8 letters:
mutagens

Word definitions for mutagens in dictionaries

Wiktionary Word definitions in Wiktionary
n. (plural of mutagen English)

Usage examples of mutagens.

Fisher also thought that they were sick and dying from the effect of living among low-level mutagens that had slowly soaked into their bones.