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Answer for the clue "A highly contagious viral disease characterized by fever and weakness and skin eruption with pustules that form scabs that slough off leaving scars ", 7 letters:
variola

Word definitions for variola in dictionaries

Wikipedia Word definitions in Wikipedia
Variola may refer to: Variola caprina , the virus that causes goatpox Variola major, the virus that causes smallpox Variola minor, the virus that causes a variant of smallpox Variola porcina, the virus that causes swinepox Variola (fish) , a genus of fish ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Variola \Va*ri"o*la\, n. [LL., fr. L. varius various. See Various .] (Med.) The smallpox.

Wiktionary Word definitions in Wiktionary
n. (context diseases English) smallpox

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
"smallpox," 1771, medical Latin diminutive of Latin varius "changing, various," in this case "speckled, spotted" (see vary ).

WordNet Word definitions in WordNet
n. a highly contagious viral disease characterized by fever and weakness and skin eruption with pustules that form scabs that slough off leaving scars [syn: smallpox , variola major ]

Usage examples of variola.

According to Dupony, the first document mentioning variola was in 570 A.

This disease may be distinguished from variola and varioloid by the shortness of the period of invasion, the mildness of the symptoms, and the absence of the deep, funnel-shaped depression of the vesicles, so noticeable in variola.

As for the yellowness like a garment, that is too familiar to the eyes of all who have ever looked on the hideous mask of confluent variola.

In addition to the Bacillus anthracis anthrax that was identified that first day, based on the symptoms, it was quickly determined that Variola major – hemorrhagic, the most fatal version of small pox, and Yersinia pestis, commonly known as the Plague, had all been involved in the weapon that was employed against the United States and the rest of the free world.

Long before the Crossings, such plagues as varicella, diphtheria, influenza, rubella, epidemic roseola, morbilli, scarlatina, variola, typhoid, typhus, poliomyelitis, tuberculosis, hepatitis, cytomegalovirus herpes, and gonococcal were eliminated by vaccination .

The variola virus, or smallpox, which, thank God, we don't see anymore, and molluscum contagiosum.

The variola would speed its way from the respiratory tract to the lymph nodes, then spread to the spleen, bone marrow, and other lymphatic organs.

They chose the smallpox virus, variola, as the most likely candidate for total extinction, because it lives only in people.

All indicators pointed to the devastating, disfiguring disease variola major, more commonly known as smallpox.