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Answer for the clue "Often results in marked cognitive and personality changes ", 9 letters:
leukotomy

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Word definitions for leukotomy in dictionaries

WordNet Word definitions in WordNet
n. surgical interruption of nerve tracts to and from the frontal lobe of the brain; often results in marked cognitive and personality changes [syn: lobotomy , leucotomy , prefrontal lobotomy , prefrontal leukotomy , prefrontal leucotomy , frontal lobotomy ...