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Answer for the clue "Antihistamine (trade name Benadryl) used to treat allergic reactions involving the nasal passages (hay fever) and also to treat motion sickness ", 8 letters:
benadryl

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Wikipedia Word definitions in Wikipedia
Benadryl is a brand name for a number of different medications. In the United States and Canada, it contains the first-generation antihistamine diphenhydramine . In the United Kingdom, it contains either the antihistamine acrivastine (marketed as Benadryl ...