YSM may refer to:
- Yale School of Medicine, the graduate medical school at Yale University in New Haven, Connecticut.
- Yale Scientific Magazine, a scientific magazine published quarterly by undergraduate students from Yale University
- Yudh Seva Medal, an Indian military decoration
- Yahoo! Search Marketing, a keyword-based Internet advertising service
- Fort Smith Airport (IATA airport code), in the Northwest Territories, Canada
- Yourdon Structured Method, one of the structured design methods in software development life cycle