YME can refer to:
- Yellow Medicine East High School, located in Granite Falls, Minnesota, United States.
- Yellow Medicine County, Minnesota located in Minnesota, United States.
- The IATA code for Matane Airport located in Quebec, Canada.
- The Yahoo! Music Engine.
- Yamaha Motor Europe.
- Y-ME National Breast Cancer Organization, a nonprofit providing support to breast cancer patients.
- Yme field, a small oil field located in the North Sea
- Yme or Ymir, a giant/jotun in Norse mythology.
- Young Money Entertainment, Record label
Yme (name), a Dutch given name