WSE may refer to:
- Warsaw School of Economics
- Warsaw Stock Exchange
- Widescreen Enhanced (16:9 aspect ratio)
- Wimbledon School of English, London
- Wise Script Package Editor
- World Standard English
- World Stock Exchange
- Windows Security Essentials, a free antivirus product by Microsoft that provides protection against malware such as computer viruses, spyware, rootkits, and trojan horses.
- Web Services Enhancements, an add-on to the Microsoft .NET Framework which implements additional web service specifications, chiefly in areas such as security, reliable messaging, and sending attachments.
- Wall Street English