What is "what's the difference"

phr. 1 How are they different 2 (context idiomatic English) The difference doesn't matter; so what.

What's the Difference may refer to:

• What's the Difference?, book by John Piper
• "What's the Difference" (song), song by Dr. Dre
• "Eyelash Curlers & Butcher Knives (What's the Difference?)", song by Jeffree Star
• What's the Difference (TV movie), 1986 TV movie about IVF starring Debra Lawrance