VSM can mean:
- Value Stream Mapping
- Variance Shadow Map
- Vector space model
- Viable System Model by operations researcher and cybernetician Stafford Beer
- Vascular smooth muscle
- City University of Seattle (Vysoká Škola Manažmentu) – private college in Slovakia
- Veluwsche Stoomtrein Maatschappij – railway in the Netherlands
- Vena saphena magna
- Vibrating sample magnetometer - a scientific instrument to measure magnetic properties.
- Vickers, Sons and Maxim a British armaments and ammunition manufacturer of the early 20th century
- Vishisht Seva Medal – one of the military awards and decorations of the Indian Armed Forces.
- Voluntary Student Membership