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Douglas Harper's Etymology Dictionary
twi-

word-forming element meaning "two, twice, double, in two ways," from Old English twi- "two, in two ways, twice, double," from Proto-Germanic *twi- (cognates: Old Frisian twi-, Old Norse tvi-, Dutch twee-, Old High German zwi-, German zwei-), from PIE *dwis (cognates: Sanskrit dvi-, Greek di-, Old Latin dvi-, Latin bi-, Lithuanian dvi-), from *dwo "two" (see two). Cognate with bi-. Older instances of it include Middle English twinter "two years old" (c.1400, of cattle, sheep, etc.), reduced from Old English twi-wintre, and Old English twispræc "double or deceitful speech."

Wiktionary
twi-

pre. 1 (context rare or no longer productive English) two 2 (context rare or no longer productive English) double, both