TGU may refer to:
- Transglobal Underground, a London-based music collective
- Toncontín International Airport (IATA code: TGU), an international airport in Tegucigalpa, Honduras
- Тартуский государственный университет (Tartuskiy gosudárstvennyy universitét) - Tartu State University, former name of the University of Tartu
- Triple Glazed Unit, a sealed glass panel made of 3 panes of glass.