Douglas Harper's Etymology Dictionary
taedium vitae
Latin, "weariness of life; a deep disgust with life tempting one to suicide."
Wiktionary
taedium vitae
n. Profound ennui or weariness of one's life.
Usage examples of "taedium vitae".
Superintendent Jury was coming through the door of the hotel, saw him sitting here, obviously realized he was in the throes of taedium vitae, and quickly came over with the other detective, Lasko.
But worse than that for our purposes was his case-book showing long-drawn-out histories of general bilious indisposition, melancholy, taedium vitae sometimes reaching mere despair, extreme irascibility: all this with no known agent, though autopsy showed an enlarged quadrate lobe studded with yellow nodules the size of a pea.