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SMZ may refer to:

As an abbreviation:

  • Sulfamethazine, an antibiotic whose abbreviations include SMZ
  • Sulfamethoxazole, an antibiotic whose abbreviations include SMZ
  • Silver Mt. Zion, root of the many names of a Canadian band abbreviated SMZ
  • Saber Marionette Z, fictional manga/anime character in Saber Marionette
  • South Manchuria Railway Zone, in China, abbreviated SMR, also called SMZ
  • SMZ connector, a miniature-type RF connector
  • Stoomvaart Maatschappij Zeeland (1875–1989), ship company now owned by Stena Line Holland BV
  • Serpukhovskiy Moto Zavod ( Serpukov Motor Factory), Russian factory of SeAZ's SZ cycle-car
  • Southern Marginal Zone, in South Africa and Zimbabwe, part of the Limpopo Belt
  • Schloegl Mang Zender (SMZ 250), a machine designed for motorcycle racer Anton Mang

As a code:

  • Stoelmans Eiland Airstrip, an airport in Surinam, IATA code SMZ
  • RAF Scampton, a Royal Air Force station in the UK, ICAO airline designator SMZ
  • Sarai Mir, a town and railway station in India, station code SMZ
  • Sisak–Moslavina County (Sisačko-Moslavačka Županija), in Croatia, locally abbreviated SMZ
  • Simeku language or Simeku, a South Bougainville language (East Papua), ISO 639-3 language code smz