SFB may refer to:
- San Francisco Bay
- San Francisco Ballet
- Securities and Futures Bureau, an agency in Taiwan
- Skype for Business
- Segmented filamentous bacteria
- Sender Freies Berlin (Radio Free Berlin), a German public broadcaster now part of Rundfunk Berlin-Brandenburg
- The IATA airport code for Orlando Sanford International Airport
- the initials for Star Fleet Battles, a tactical strategy board game set in the Star Fleet Universe
- Scouting for Boys, the book on scouting by Baden-Powell
- Collaborative Research Centers (SFB - Sonderforschungbereich) of the German Science Foundation (DFG - Deutsche Forschungsgemeinschaft)
- Statens filmgranskningsbyrå, the game and movie rating board of the Finnish Ministry of Education
- Stochastic Fair Blue, an active queue management algorithm.
- N-succinimidyl 4-fluorobenzoate, a compound used to label proteins and peptides for positron emission tomography.