Sepen may refer to:
- Sepen (sauce), a hot sauce in Tibetan cuisine
- Sepen (language) one of the Ramu languages of Papua New Guinea
Sepen is a Tibetan cuisine hot sauce made with chillies as the primary ingredient and other spices depending on recipe. It can be made on a tomato base or can include vegetables like onion and celery. It exists in both thick and chunky versions as well as smooth ones. It can be served with all meals and is used to spice the usually mild Tibetan food.