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Wiktionary

separase

n. A cysteine protease responsible for triggering anaphase by hydrolyse cohesin.

Wikipedia

Separase

Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase. In humans, separin is encoded by the ESPL1 gene.