SEMC may refer to:
- Sony Ericsson Mobile Communications AB
- The ICAO airport code for Macas Airport in Macas, Ecuador
- Shillong Engineering and Management College
- Southern and Eastern Mediterranean Countries (SEMCs), an acronym used in European Institute for the Mediterranean publications and other EU publications and referring to the ensemble of non-European countries along the Mediterranean shoreline, i.e. Morocco, Algeria, Tunisia, Libya, Egypt, Jordan, Israel, Palestinian Territories, Lebanon and Syria, and sometimes including Turkey and Cyprus.
- Super Evil Megacorp, the makers of the video game Vainglory