OWC can refer to:
- Office Web Components, a group of OLE components implemented as ActiveX controls in Microsoft Office 2000, Office XP and Office 2003
- Osu! World Cup, the greatest official annual competition of PC rhythm game Osu!.
- Open wheel car, describes cars with the wheels outside the car's main body and, in most cases, one seat.
- Oscillating water column, a wave power technology
- Oil-water contact, the interface between layers of oil and water in hydrocarbon reservoirs
- Own work capitalized, the value of work that was performed for own purposes and is capitalized in the balance sheet as part of fixed assets
- "OWC", song from the album Isola by the Swedish rock band Kent
- original wood case, wine packaging
- Other World Computing (aka Macsales.com), a PC computer component supplier specializing in Apple computer products
- Optical wireless communications, a form of telecommunication in the optical spectrum