Crossword clues for oncogene
Douglas Harper's Etymology Dictionary
Wiktionary
n. (context oncology genetics English) Any gene that contributes to the conversion of a normal cell into a cancerous cell when mutated or expressed at high levels.
WordNet
n. a gene that causes normal cells to change into cancerous tumor cells [syn: transforming gene]
Wikipedia
An oncogene is a gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels.
Most normal cells will undergo a programmed form of rapid cell death ( apoptosis) when critical functions are altered. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors, such as viral infection, to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target the proteins encoded by oncogenes.
Oncogene is a peer-reviewed scientific journal published by the Nature Publishing Group addressing cancer cell genetics and the structure and function of oncogenes.
According to the Journal Citation Reports, the journal received a 2014 impact factor of 8.459, ranking it 23rd out of 289 journals in the category Biochemistry & Molecular Biology, 13th out of 211 journals in the category Oncology, 26th out of 184 journals in the category Cell Biology and 12th out of 167 journals in the category Genetics & Heredity.
Usage examples of "oncogene".
A mutated oncogene may direct a cell to reproduce wildly, and this means, in turn, that more mutations are likely to occur.
In 1993, the Swiss drug company Ciba-Geigy synthesized hundreds of thousands of possible targeted therapies, which it then tested against dozens of oncogene proteins.
It is a small molecule that, like STI-571, blocks PDGF-r, an oncogene that is believed to be important in the proliferation of a number of intractable cancers.
Herceptin targets Her-2, a protein produced by an oncogene that is found in between twenty and thirty per cent of breast-cancer cases.
The composer knew, weeks before any physician, that the oncogene had been triggered.
His parents must have bribed a technician to conceal the oncogene and Whittington allele in one or the other.
Artist, Milena the Angel, Milena the oncogene, Milena who carried the Mind of Heather, and the Milena who remembered Rolfa.
In the lab, the chemicals that are being screened are interacting only with the proteins of oncogenes or tumor-suppressor genes.
Not after he edited out the oncogenes and selected for longevity, good eyesight, good teeth, and the rest of it.
The immunity-suppressing drugs and the others that resuppressed triggered oncogenes made him sicker than the radiation had.
But when an oncogene is activated, the wrong messages are sent to the affected cell and it becomes transformed into a cancer cell.
Because we’ve also got an added plasmid to keep oncogenes from ever expressing themselves.
People are worried that inserted genes might cause proto-onco genes to become oncogenes, turning the involved cell into a cancer.
It's an appropriate name, because the DNA in cancer cells is different from the stuff in normal body cells, in that the harmless proto-oncogenes have been transformed into new, malignant oncogenes.