OAE could refer to:
- Oceanic Anoxic event, in which the Earth's oceans become completely depleted of oxygen below the surface levels.
- Orchestra of the Age of Enlightenment, a British period instrument orchestra.
- Otoacoustic emissions, involved in testing hearing.
- Omni Air Express, United States ( ICAO operator designator)
- Overall Asset Effectiveness
- Overall Acquisition Engine
- Operation Active Endeavour
- Oddworld: Abe's Exoddus a platform game made by Oddworld Inhabitants released in 1998.